ON THE BOARD (publication submitted, ACCEPTED)
On the importance of pharmacokinetics and pharmacodynamics in engineering sciences as an inter- and multidisciplinary field: an introductory analysis
This paper was awarded by the commission of SIMPEP a position of highlight, amongst the best papers of 2014. The authors are honored and pretty gratified by the gesture of recognition of importance and impact of the research. Thanks SIMPEP for the kindness! Jorge Guerra Pires
Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR) Rome, Italy
CAPES Foundation, Ministry of Education of Brazil
University of L'Aquila, Italy
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR) Rome, Italy
CAPES Foundation, Ministry of Education of Brazil
Email: jorgeguerrapires@yahoo.com.br
Roberto Maggio
Department of Biotechnological and Applied Clinical Sciences
University of L'Aquila
Email: roberto.maggio@univaq.it
Pasquale Palumbo
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR) Rome, Italy
Email: pasquale.palumbo@iasi.cnr.it
Cosiglio Nazionale delle Ricerche (CNR) Rome, Italy
Email: pasquale.palumbo@iasi.cnr.it
Costanzo Manes
Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Institute of Systems
Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR)Rome , Italy
Email: costanzo.manes@univaq.it
Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Cosiglio Nazionale delle Ricerche (CNR)
Email: costanzo.manes@univaq.it
Submitted to SIMPEP
Language: English
Area: Engineering Teachings
Abstract:
Amongst the entire
potential spectrum of expansion of the engineering sciences as an omnipresent
field, we might point out the studies of drugs, applied pharmacology, as a good
candidate for receiving attention. The common problematic encountered in the
literature faced by the industry of drugs is the high cost for drug development
and systematic approaches are demanded. Based upon the authors’ viewpoint, by
no means it interferes with the natural and important chase of identity by
(industrial) production engineering. On the hope of bringing the discussions to
engineering’s territory, we borrow several insights from mathematical modeling;
it is presented a simple case study, tumor treatment using optimal control, we
shall see that it is possible with simple tools already standard in engineering
to design a optimal regimen for the tumor therapy, given that the tumor respects
our model. On the example presented, we shall see that tools already part of
(industrial) production engineering, with exception of optimal control theory,
is enough for getting insights. The ideas discussed herein could diminish the
cost of drug development if properly extended. As any endeavor, we have
challenges, such as to gain the credibility necessary for really using those
models in the academy and industry.
Key-words: Teachings
of Engineering Sciences; Simulations; Pharmacology; Optimal Control; Cancer
Therapy;
On the importance of optimal control theory in
engineering sciences as a complementary and supplementary methodology to
Operations Research: a case-study analysis
Jorge Guerra Pires
Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR) Rome, Italy
CAPES Foundation, Ministry of Education of Brazil
University of L'Aquila, Italy
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR) Rome, Italy
CAPES Foundation, Ministry of Education of Brazil
Email: jorgeguerrapires@yahoo.com.br
Costanzo Manes
Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR)Rome , Italy
Email: costanzo.manes@univaq.it
Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Cosiglio Nazionale delle Ricerche (CNR)
Email: costanzo.manes@univaq.it
Pasquale Palumbo
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale delle Ricerche (CNR) Rome, ItalyEmail: pasquale.palumbo@iasi.cnr.it
Cosiglio Nazionale delle Ricerche (CNR) Rome, ItalyEmail: pasquale.palumbo@iasi.cnr.it
Submitted to SIMPEP
Language: English
Area: Mathematical Programming
Abstract:
On this work it is discussed on the optimal control
theory as supplementary and complementary methodological procedure to
operations researches. Accordingly, it is disserted on the importance of
optimal control theory as an essential tool for supporting operations research
on its chases for enhancing
processes by means of optimization. Here two case studies are presented taken
from the literature of production (industrial)
engineering: phototherapy applied to neonatal affected by the syndrome called
jaundice and optimal production of protein. Furthermore, we have made use of
numerical schemes for solving ordinary differential equations to achieve the
optimal controls: the forward-backward sweep method and the Runge-Kutta 4. The
paper is organized in an introduction, methodological procedures, the case
studies, the conclusions and final remarks, and finally, the references. It was
strived to achieve a paper in a layman terms, for a general audience.
Keywords: Optimal
Control Theory; Operations Research; Numerical Schemes; Pontryagin’s Maximum
Principle.
