Stochastic Models in Medicine and Life Sciences (IASI-CNR)

Incoming (Publication)

Poster Section: Como Lake Summer School

On the mathematical modeling in gene expression estimation: an initial discussion on PBM and BM

Jorge Guerra Pires , jorgeguerrapires@yahoo.com.br

Department of Information Engineering, Computer Science and Mathematics
University of L'Aquila, Italy
Institute of Systems Analysis and Computer Science (IASI)
Cosiglio Nazionale  delle Ricerche (CNR) Rome, Italy

CAPES Foundation, Ministry of Education of Brazil 

Abstract— with the advent of computers, new technologies could finally rise up. Maybe one of the most polemic and prominent ones are the methods from artificial intelligence such as neural networks or even fuzzy logic. In this short paper we discuss a set of insights generated by the authors after studying the two-communities currently predominant in applied mathematical modeling. We conclude that applied mathematical models, here focused on biological systems, might beneath considerably by recognizing middle-way models between classical (traditional) mathematics and knowledge-based models. 

Keywords—systems biology; pharmacology; biomathematics; knowledge-based modeling; state-space-based models.

  Download files: PDF 1, PDF 2.

Comments

PBM stands for Partial Blind Models and BM for Blind Models. This idea came to me by accident when I was trying to express myself during the pathway of my thesis of master of science, I have used those terms for the very first time on Pires (2013b), then replicated on Pires (2013a). The idea sounds trivial and without any innovation, nonetheless recently I have taken it serious and based upon my readings, this is really interesting for the upcoming generation of scientists.

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Pires JG (2013b). Neural Networks in Transcription Networks: An alternative and complementary approach for the observer-based method. 1st BRICS Countries  & 11th Brazilian Congress on Computational Intelligence. Brazil. 2: 1-2. 

Pires JG (2013a). On the mathematical modelling in gene expression estimation. II Workshop and School on Dynamics, Transport and Control in Complex Networks  (ComplexNet), Ribeirão Preto, SP, Brazil. 21-26/October. Poster.

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Jorge Pires